diff --git a/.travis.yml b/.travis.yml
index c05689b..a70fd87 100644
--- a/.travis.yml
+++ b/.travis.yml
@@ -35,6 +35,18 @@ matrix:
     - python: "3.8"
       env:
         - TOXENV=py38-with_coverage
+    - python: "pypy"
+      env:
+        - TOXENV=pypy-without_coverage
+    - python: "pypy"
+      env:
+        - TOXENV=pypy-with_coverage
+    - python: "pypy3"
+      env:
+        - TOXENV=pypy3-without_coverage
+    - python: "pypy3"
+      env:
+        - TOXENV=pypy3-with_coverage
 
 install:
   - pip install coveralls
diff --git a/README.rst b/README.rst
index bc60fbe..96102a6 100644
--- a/README.rst
+++ b/README.rst
@@ -68,7 +68,8 @@ For more info, see the `documentation <http://fuzzysearch.rtfd.org>`_.
 Installation
 ------------
 
-``fuzzysearch`` supports Python versions 2.7 and 3.5+.
+``fuzzysearch`` supports Python versions 2.7 and 3.5+, as well as PyPy 2.7 and
+3.6.
 
 .. code::
 
diff --git a/setup.py b/setup.py
index 01c7683..8bcd443 100644
--- a/setup.py
+++ b/setup.py
@@ -136,6 +136,7 @@ def run_setup(with_binary=True):
             'Programming Language :: Python :: 3.7',
             'Programming Language :: Python :: 3.8',
             'Programming Language :: Python :: Implementation :: CPython',
+            'Programming Language :: Python :: Implementation :: PyPy',
             'Topic :: Software Development :: Libraries :: Python Modules',
         ],
         cmdclass={'build_ext': ve_build_ext},
diff --git a/tox.ini b/tox.ini
index 3b381b6..224b539 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,5 @@
 [tox]
-envlist = py{27,35,36,37,38}-{with,without}_coverage-{,appveyor}
+envlist = {py27,py35,py36,py37,py38,pypy,pypy3}-{with,without}_coverage-{,appveyor}
 
 [testenv]
 install_command =
@@ -13,11 +13,10 @@ install_command =
 deps =
     ; use specific versions of testing tools with which this is known to work
     with_coverage: coverage>=5,<6
-    py{27}: unittest2==1.1.0
-    py{27}: mock==1.3.0
-    py{27}: biopython<=1.76
-    py{35}: biopython<=1.76
-    py{36,37,38}: biopython
+    {py27,pypy}: unittest2==1.1.0
+    {py27,pypy}: mock==1.3.0
+    {py27,py35}: biopython<=1.76
+    {py36,py37,py38,pypy3}: biopython
 whitelist_externals =
     mv
 commands =
@@ -26,16 +25,16 @@ commands =
     ; * if running with coverage, merge the coverage run results from both runs
     ; * for Python 2.6 use the unit2 script since -m unittest2 doesn't work
     ;     (but when running with coverage, coverage run -m unittest2 works)
-    py{27}-without_coverage: {envbindir}/unit2 discover tests -t {toxinidir}
-    py{27}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest2 discover tests
-    py{35,36,37,38}-without_coverage: {envpython} -m unittest discover tests
-    py{35,36,37,38}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
+    {py27,pypy}-without_coverage: {envbindir}/unit2 discover tests -t {toxinidir}
+    {py27,pypy}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest2 discover tests
+    {py35,py36,py37,py38,pypy3}-without_coverage: {envpython} -m unittest discover tests
+    {py35,py36,py37,py38,pypy3}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
     with_coverage: mv .coverage .coverage.with_extensions
     {envpython} -c 'import os; [os.remove(os.path.join(d, fn)) for (d, dns, fns) in os.walk(os.path.join(r"{envsitepackagesdir}", "fuzzysearch")) for fn in fns if fn.endswith((".so", ".pyd"))]'
-    py{27}-without_coverage: {envbindir}/unit2 discover tests -t {toxinidir}
-    py{27}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest2 discover tests
-    py{35,36,37,38}-without_coverage: {envpython} -m unittest discover tests
-    py{35,36,37,38}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
+    {py27,pypy}-without_coverage: {envbindir}/unit2 discover tests -t {toxinidir}
+    {py27,pypy}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest2 discover tests
+    {py35,py36,py37,py38,pypy3}-without_coverage: {envpython} -m unittest discover tests
+    {py35,py36,py37,py38,pypy3}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
     with_coverage: mv .coverage .coverage.no_extensions
     with_coverage: {envbindir}/coverage combine
 basepython =
@@ -44,4 +43,6 @@ basepython =
     py36: python3.6
     py37: python3.7
     py38: python3.8
+    pypy: pypy
+    pypy3: pypy3
     appveyor: {env:PYTHON:}\\python.exe