diff --git a/README.rst b/README.rst
index a2f182a..645b59b 100644
--- a/README.rst
+++ b/README.rst
@@ -62,6 +62,8 @@ For more info, see the `documentation <http://fuzzysearch.rtfd.org>`_.
 Installation
 ------------
 
+`fuzzysearch` supports Python versions 2.7 and 3.5+.
+
 .. code::
 
     $ pip install fuzzysearch
diff --git a/appveyor.yml b/appveyor.yml
index 564e38f..591f17f 100644
--- a/appveyor.yml
+++ b/appveyor.yml
@@ -10,13 +10,6 @@ environment:
     - PYTHON: 'C:\Python27-x64'
       TOX_ENV: 'py27'
       PYTHON_APPDATA_DIR: 'C:\Users\appveyor\AppData\Roaming\Python'
-    - PYTHON: 'C:\Python34'
-      TOX_ENV: 'py34'
-      PYTHON_APPDATA_DIR: 'C:\Users\appveyor\AppData\Roaming\Python'
-#    - PYTHON: 'C:\Python34-x64'
-#      TOX_ENV: 'py34'
-#      DISTUTILS_USE_SDK: '1'
-#      PYTHON_APPDATA_DIR: 'C:\Users\appveyor\AppData\Roaming\Python'
     - PYTHON: 'C:\Python35'
       TOX_ENV: 'py35'
       PYTHON_APPDATA_DIR: 'C:\Users\appveyor\AppData\Roaming\Python\Python35'
diff --git a/setup.py b/setup.py
index de3f6d4..9b25c83 100644
--- a/setup.py
+++ b/setup.py
@@ -131,7 +131,6 @@ def run_setup(with_binary=True):
             'Programming Language :: Python :: 2',
             'Programming Language :: Python :: 2.7',
             'Programming Language :: Python :: 3',
-            'Programming Language :: Python :: 3.4',
             'Programming Language :: Python :: 3.5',
             'Programming Language :: Python :: 3.6',
             'Programming Language :: Python :: 3.7',
diff --git a/tox.ini b/tox.ini
index ea8e426..3b381b6 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,5 +1,5 @@
 [tox]
-envlist = py{27,34,35,36,37,38}-{with,without}_coverage-{,appveyor}
+envlist = py{27,35,36,37,38}-{with,without}_coverage-{,appveyor}
 
 [testenv]
 install_command =
@@ -12,18 +12,10 @@ install_command =
 ;    CPPFLAGS=-Qunused-arguments
 deps =
     ; use specific versions of testing tools with which this is known to work
-    py{34}-with_coverage: coverage<5
-    py{27,35,36,37,38}-with_coverage: coverage>=5,<6
+    with_coverage: coverage>=5,<6
     py{27}: unittest2==1.1.0
     py{27}: mock==1.3.0
     py{27}: biopython<=1.76
-    py{34}: setuptools<44
-    py{34}: pip<19.2
-    ; biopython 1.74 has numpy as a dependency, but the version must be
-    ; limited to work on Python 3.4. (i.e `pip install numpy` no longer works
-    ; on Python 3.4!)
-    py{34}: numpy<1.16
-    py{34}: biopython<=1.74
     py{35}: biopython<=1.76
     py{36,37,38}: biopython
 whitelist_externals =
@@ -36,19 +28,18 @@ commands =
     ;     (but when running with coverage, coverage run -m unittest2 works)
     py{27}-without_coverage: {envbindir}/unit2 discover tests -t {toxinidir}
     py{27}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest2 discover tests
-    py{34,35,36,37,38}-without_coverage: {envpython} -m unittest discover tests
-    py{34,35,36,37,38}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
+    py{35,36,37,38}-without_coverage: {envpython} -m unittest discover tests
+    py{35,36,37,38}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
     with_coverage: mv .coverage .coverage.with_extensions
     {envpython} -c 'import os; [os.remove(os.path.join(d, fn)) for (d, dns, fns) in os.walk(os.path.join(r"{envsitepackagesdir}", "fuzzysearch")) for fn in fns if fn.endswith((".so", ".pyd"))]'
     py{27}-without_coverage: {envbindir}/unit2 discover tests -t {toxinidir}
     py{27}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest2 discover tests
-    py{34,35,36,37,38}-without_coverage: {envpython} -m unittest discover tests
-    py{34,35,36,37,38}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
+    py{35,36,37,38}-without_coverage: {envpython} -m unittest discover tests
+    py{35,36,37,38}-with_coverage: {envbindir}/coverage run --source=fuzzysearch -m unittest discover tests
     with_coverage: mv .coverage .coverage.no_extensions
     with_coverage: {envbindir}/coverage combine
 basepython =
     py27: python2.7
-    py34: python3.4
     py35: python3.5
     py36: python3.6
     py37: python3.7