diff --git a/scapy/utils6.py b/scapy/utils6.py
index 51be5b5d4..29e937dd3 100644
--- a/scapy/utils6.py
+++ b/scapy/utils6.py
@@ -250,7 +250,7 @@ def in6_addrtovendor(addr):
     is returned on error, "UNKNOWN" if the vendor is unknown.
     """
     mac = in6_addrtomac(addr)
-    if mac is None:
+    if mac is None or conf.manufdb is None:
         return None
 
     res = conf.manufdb._get_manuf(mac)