diff --git a/numpy/core/include/numpy/npy_cpu.h b/numpy/core/include/numpy/npy_cpu.h
index 84653ea18..ca25a5715 100644
--- a/numpy/core/include/numpy/npy_cpu.h
+++ b/numpy/core/include/numpy/npy_cpu.h
@@ -82,6 +82,8 @@
     #define NPY_CPU_ARCEL
 #elif defined(__arc__) && defined(__BIG_ENDIAN__)
     #define NPY_CPU_ARCEB
+#elif defined(__EMSCRIPTEN__)
+    #define NPY_CPU_EMSCRIPTEN
 #else
     #error Unknown CPU, please report this to numpy maintainers with \
     information about your platform (OS, CPU and compiler)
diff --git a/numpy/core/include/numpy/npy_endian.h b/numpy/core/include/numpy/npy_endian.h
index 1a42121db..5a43b14a8 100644
--- a/numpy/core/include/numpy/npy_endian.h
+++ b/numpy/core/include/numpy/npy_endian.h
@@ -46,7 +46,8 @@
             || defined(NPY_CPU_SH_LE)   \
             || defined(NPY_CPU_MIPSEL)  \
             || defined(NPY_CPU_PPC64LE) \
-            || defined(NPY_CPU_ARCEL)
+            || defined(NPY_CPU_ARCEL)   \
+            || defined(NPY_CPU_EMSCRIPTEN)
         #define NPY_BYTE_ORDER NPY_LITTLE_ENDIAN
     #elif defined(NPY_CPU_PPC)          \
             || defined(NPY_CPU_SPARC)   \