diff --git a/.circleci/config.yml b/.circleci/config.yml
index 1a4dc6d8f..407a27ae6 100644
--- a/.circleci/config.yml
+++ b/.circleci/config.yml
@@ -6,7 +6,7 @@ defaults: &defaults
     # Note: when updating the docker image version,
     #       make sure there are no extra old versions lying around.
     #       (e.g. `rg -F --hidden <old_tag>`)
-    - image: pyodide/pyodide-env:20241028-chrome130-firefox131
+    - image: pyodide/pyodide-env:20241106-chrome130-firefox132
   environment:
     - EMSDK_NUM_CORES: 3
       EMCC_CORES: 3
@@ -339,7 +339,8 @@ jobs:
           command: |
             make npm-link
             pip install -r requirements.txt
-            pytest -s benchmark/stack_usage.py --rt node,chrome,firefox | sed -n 's/## //pg'
+            # TODO(cclauss): Re-add 'firefox' below.
+            pytest -s benchmark/stack_usage.py --rt node,chrome | sed -n 's/## //pg'
 
   test-js:
     <<: *defaults
diff --git a/.devcontainer/devcontainer.json b/.devcontainer/devcontainer.json
index 9ecfffcad..c180d848a 100644
--- a/.devcontainer/devcontainer.json
+++ b/.devcontainer/devcontainer.json
@@ -1,7 +1,7 @@
 {
   "name": "Docker",
   // keep in sync with "run_docker"
-  "image": "pyodide/pyodide-env:20241028-chrome130-firefox131",
+  "image": "pyodide/pyodide-env:20241106-chrome130-firefox132",
   "remoteUser": "root",
   "onCreateCommand": ".devcontainer/onCreate-docker.sh"
 }
diff --git a/Dockerfile b/Dockerfile
index 10c084043..6813b87b6 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -1,5 +1,5 @@
 FROM node:20.11-bookworm-slim AS node-image
-FROM python:3.12.1-slim-bookworm
+FROM python:3.12.7-slim-bookworm
 
 # Requirements for building packages
 RUN apt-get update \
@@ -104,7 +104,7 @@ RUN if [ $CHROME_VERSION = "latest" ]; \
   then CHROME_VERSION_FULL=$(wget --no-verbose -O - "https://googlechromelabs.github.io/chrome-for-testing/LATEST_RELEASE_STABLE"); \
   else CHROME_VERSION_FULL=$(wget --no-verbose -O - "https://googlechromelabs.github.io/chrome-for-testing/LATEST_RELEASE_${CHROME_VERSION}"); \
   fi \
-  && CHROME_DOWNLOAD_URL="https://dl.google.com/linux/chrome/deb/pool/main/g/google-chrome-stable/google-chrome-stable_${CHROME_VERSION_FULL}-1_amd64.deb" \
+  && CHROME_DOWNLOAD_URL="https://dl.google.com/linux/direct/google-chrome-stable_current_amd64.deb." \
   && CHROMEDRIVER_DOWNLOAD_URL="https://storage.googleapis.com/chrome-for-testing-public/${CHROME_VERSION_FULL}/linux64/chromedriver-linux64.zip" \
   && wget --no-verbose -O /tmp/google-chrome.deb ${CHROME_DOWNLOAD_URL} \
   && apt-get update \
diff --git a/Makefile.envs b/Makefile.envs
index 54fea4eb4..34b54834f 100644
--- a/Makefile.envs
+++ b/Makefile.envs
@@ -1,9 +1,9 @@
-export PYVERSION ?= 3.12.1
+export PYVERSION ?= 3.12.7
 export PYODIDE_EMSCRIPTEN_VERSION ?= 3.1.58
 export PYODIDE_VERSION ?= 0.27.0.dev0
 export PYODIDE_ABI_VERSION ?= 2024_0
 
-export PYTHON_ARCHIVE_SHA256=d01ec6a33bc10009b09c17da95cc2759af5a580a7316b3a446eb4190e13f97b2
+export PYTHON_ARCHIVE_SHA256=73ac8fe780227bf371add8373c3079f42a0dc62deff8d612cd15a618082ab623
 
 ifdef CPYTHON_DEBUG
 	export CPYTHON_ABI_FLAGS=d
diff --git a/docs/project/changelog.md b/docs/project/changelog.md
index 67a093d8d..39bc18750 100644
--- a/docs/project/changelog.md
+++ b/docs/project/changelog.md
@@ -16,6 +16,9 @@ myst:
 
 ## Unreleased
 
+- {{ Enhancement }} Upgrade to Python 3.12.7.
+  {pr}`5149`
+
 - {{ Enhancement }} Add unix-timezones module, which installs Unix compatible
   timezone data in /usr/share/zoneinfo, for use with C/C++ libraries which do
   timezone handling.
diff --git a/docs/requirements-doc.txt b/docs/requirements-doc.txt
index b62d33da3..c66b0e76a 100644
--- a/docs/requirements-doc.txt
+++ b/docs/requirements-doc.txt
@@ -22,4 +22,4 @@ pyodide-build>=0.27.3
 micropip==0.2.2
 jinja2>=3.0
 ruamel.yaml
-sphinx-js @ git+https://github.com/pyodide/sphinx-js-fork@14958086d51939ae4078751abec004e1f3fea1fe
+sphinx-js @ git+https://github.com/pyodide/sphinx-js-fork@1428f1547b510a1574c227ced4356ba546a21f74
diff --git a/packages/pygame-ce/meta.yaml b/packages/pygame-ce/meta.yaml
index 464c3dce7..030adc389 100644
--- a/packages/pygame-ce/meta.yaml
+++ b/packages/pygame-ce/meta.yaml
@@ -31,6 +31,7 @@ build:
     -sUSE_LIBPNG=1
     -sUSE_GIFLIB=1
     -sUSE_HARFBUZZ=1
+    -Wno-unreachable-code-fallthrough
   ldflags: |
     -sRELOCATABLE=1
     -sUSE_SDL=2
diff --git a/packages/test/meta.yaml b/packages/test/meta.yaml
index 5af447fe6..0f20fff9a 100644
--- a/packages/test/meta.yaml
+++ b/packages/test/meta.yaml
@@ -51,6 +51,7 @@ build:
       _testcapi/code.c \
       _testcapi/buffer.c \
       _testcapi/pyos.c \
+      _testcapi/run.c \
       _testcapi/file.c \
       _testcapi/codec.c \
       _testcapi/immortal.c \
diff --git a/src/core/jsproxy.c b/src/core/jsproxy.c
index 711b15e13..4e3b3d09b 100644
--- a/src/core/jsproxy.c
+++ b/src/core/jsproxy.c
@@ -1698,7 +1698,7 @@ JsArray_ass_subscript(PyObject* self, PyObject* item, PyObject* pyvalue)
     slicelength = PySlice_AdjustIndices(length, &start, &stop, step);
 
     if (pyvalue != NULL) {
-      seq = PySequence_Fast(pyvalue, "can only assign an iterable");
+      seq = PySequence_Fast(pyvalue, "must assign iterable to extended slice");
       FAIL_IF_NULL(seq);
     }
     if (pyvalue != NULL && step != 1 &&
diff --git a/src/tests/python_tests.yaml b/src/tests/python_tests.yaml
index 8e5a875d5..07869b7ec 100644
--- a/src/tests/python_tests.yaml
+++ b/src/tests/python_tests.yaml
@@ -57,10 +57,9 @@
     xfail: slow, sometimes times out
 - test_array
 - test_asdl_parser
-- test_ast:
-    xfail-safari: Stack overflow
+- test_ast.test_ast:
     skip:
-      - test_stdlib_validates # incompatible with zipimport
+      - "*_recursion_*"
 - test_asyncgen:
     xfail: async
 - test_asyncio.test_base_events:
@@ -97,6 +96,7 @@
     xfail: async
 - test_asyncio.test_ssl
 - test_asyncio.test_sslproto
+- test_asyncio.test_staggered
 - test_asyncio.test_streams:
     xfail: async
 - test_asyncio.test_subprocess:
@@ -179,9 +179,12 @@
 - test_capi.test_misc:
     skip:
       - "*subinterpreter*" # Should we disable _xxsubinterpreters in Setup.local?
+- test_capi.test_number
+- test_capi.test_run
 - test_capi.test_set
 - test_capi.test_structmembers
 - test_capi.test_sys
+- test_capi.test_tuple
 - test_capi.test_unicode
 - test_capi.test_watchers
 - test_cgi:
@@ -189,7 +192,9 @@
       - test_log # OSError: [Errno 70] Invalid seek
 - test_cgitb
 - test_charmapcodec
-- test_class
+- test_class:
+    skip:
+      - testSFBug532646 # Maximum call stack size exceeded
 - test_clinic
 - test_cmath
 - test_cmd
@@ -216,7 +221,10 @@
 - test_collections
 - test_colorsys
 - test_compare
-- test_compile
+- test_compile:
+    skip:
+      - test_compiler_recursion_limit
+      - test_extended_arg
 - test_compileall:
     xfail: multiprocessing
 - test_compiler_assemble
@@ -238,7 +246,11 @@
 - test_contextlib
 - test_contextlib_async:
     xfail: async
-- test_copy
+- test_copy:
+    skip:
+      - test_deepcopy_reflexive_dict
+      - test_deepcopy_reflexive_list
+      - test_deepcopy_reflexive_tuple
 - test_copyreg:
     xfail: dbm
 - test_coroutines:
@@ -250,7 +262,9 @@
 - test_ctypes.test_anon
 - test_ctypes.test_array_in_pointer
 - test_ctypes.test_arrays
-- test_ctypes.test_as_parameter
+- test_ctypes.test_as_parameter:
+    skip:
+      - test_recursive_as_param
 - test_ctypes.test_bitfields
 - test_ctypes.test_buffers
 - test_ctypes.test_bytes
@@ -293,7 +307,9 @@
 - test_ctypes.test_struct_fields
 - test_ctypes.test_structures:
     skip:
+      - test_array_in_struct
       - test_array_in_struct_registers # needs https://github.com/libffi/libffi/pull/818
+      - test_issue18060*
 - test_ctypes.test_unaligned_structures
 - test_ctypes.test_unicode
 - test_ctypes.test_values
@@ -320,16 +336,19 @@
     xfail: stack overflow
 - test_descrtut
 - test_devpoll
-- test_dict
+- test_dict:
+    skip:
+      - test_repr_deep
 - test_dict_version
 - test_dictcomps
-- test_dictviews
+- test_dictviews:
+    skip:
+      - test_deeply_nested_repr
 - test_difflib
 - test_dis:
     xfail-safari: safaridriver unexpectedly exited
-- test_doctest:
-    xfail: subprocess
-- test_doctest2
+- test_doctest.test_doctest
+- test_doctest.test_doctest2
 - test_docxmlrpc:
     xfail: socket
 - test_dtrace:
@@ -367,7 +386,10 @@
 - test_epoll
 - test_errno
 - test_except_star
-- test_exception_group
+- test_exception_group:
+    skip:
+      - test_deep_split
+      - test_deep_subgroup
 - test_exception_hierarchy
 - test_exception_variations
 - test_exceptions:
@@ -403,13 +425,15 @@
     skip:
       # frozen modules are disabled in runtime
       - test_unfrozen_submodule_in_frozen_package
-- test_fstring
+- test_fstring:
+    xfail-chrome: times out on Python 3.12.7
 - test_ftplib:
     xfail: socket
 - test_funcattrs
 - test_functools:
     skip:
       - "*threaded*"
+      - test_recursive_pickle
 - test_future_stmt.test_future
 - test_future_stmt.test_future_flags
 - test_future_stmt.test_future_multiple_features
@@ -540,7 +564,10 @@
     # The remaining test_io tests seem to hang too
 - test_ioctl
 - test_ipaddress
-- test_isinstance
+- test_isinstance:
+    skip:
+      - "*recursion*"
+      - "*infinite*"
 - test_iter
 - test_iterlen
 - test_itertools
@@ -555,7 +582,8 @@
 - test_json.test_pass1
 - test_json.test_pass2
 - test_json.test_pass3
-- test_json.test_recursion
+- test_json.test_recursion:
+    xfail: Stack overflow
 - test_json.test_scanstring
 - test_json.test_separators
 - test_json.test_speedups
@@ -588,7 +616,9 @@
       - test_clearcache
       - test_getline
       - test_memoryerror
-- test_list
+- test_list:
+    skip:
+      - test_repr_deep
 - test_listcomps
 - test_lltrace
 - test_locale:
@@ -727,8 +757,8 @@
     skip:
       - test_stdin # fork
 - test_pyclbr
-- test_pydoc:
-    xfail: pydoc_data unvendored
+- test_pydoc.test_pydoc:
+    xfail: Missing doc data
 - test_pyexpat
 - test_queue:
     # More than half of these make a thread
@@ -873,6 +903,8 @@
       - test_sly_relative*
       - test_extractall*
       - test_parent_symlink*
+      - test_overwrite_broken_file_symlink_as_file
+      - test_overwrite_file_as_implicit_dir
 - test_tcl
 - test_telnetlib:
     xfail: 7/19 fail with sockets
@@ -923,6 +955,7 @@
 - test_tomllib.test_misc
 - test_tools.test_freeze
 - test_tools.test_i18n
+- test_tools.test_makefile
 - test_tools.test_reindent
 - test_tools.test_sundry
 - test_trace:
@@ -974,6 +1007,7 @@
 - test_unittest.test_setups
 - test_unittest.test_skipping
 - test_unittest.test_suite
+- test_unittest.test_util
 - test_univnewlines
 - test_unpack
 - test_unpack_ex
@@ -989,8 +1023,10 @@
 - test_urllib_response
 - test_urllibnet
 - test_urlparse
-- test_userdict
-- test_userlist
+- test_userdict:
+    xfail: Stack overflow
+- test_userlist:
+    xfail: Stack overflow
 - test_userstring
 - test_utf8_mode
 - test_utf8source
@@ -1010,6 +1046,7 @@
 - test_weakset
 - test_webbrowser:
     xfail: replaced
+- test_winapi
 - test_winconsoleio
 - test_winreg
 - test_winsound
diff --git a/src/tests/test_pyodide.py b/src/tests/test_pyodide.py
index 73a97f6ce..f1b8f4d14 100644
--- a/src/tests/test_pyodide.py
+++ b/src/tests/test_pyodide.py
@@ -280,7 +280,10 @@ def test_relaxed_call():
         return [a, args, b]
 
     with pytest.raises(
-        TypeError, match="'a' parameter is positional only, but was passed as a keyword"
+        TypeError,
+        match=re.escape(
+            "test_relaxed_call.<locals>.f4() missing 1 required positional argument: 'a'"
+        ),
     ):
         relaxed_call(f4, a=2, b=7)
 
@@ -342,7 +345,10 @@ def test_relaxed_wrap():
         return [a, args, b]
 
     with pytest.raises(
-        TypeError, match="'a' parameter is positional only, but was passed as a keyword"
+        TypeError,
+        match=re.escape(
+            "test_relaxed_wrap.<locals>.f4() missing 1 required positional argument: 'a'"
+        ),
     ):
         f4(a=2, b=7)