diff --git a/Makefile b/Makefile
index 1984a8356..29fd241a5 100644
--- a/Makefile
+++ b/Makefile
@@ -59,6 +59,11 @@ build/pyodide.asm.js: \
 		let clearImmediate = globalThis.clearImmediate;\
 		let baseName, fpcGOT, dyncallGOT, fpVal, dcVal;\
 	' build/pyodide.asm.js
+	# Remove last 6 lines of pyodide.asm.js, see issue #2282
+	# Hopefully we will remove this after emscripten fixes it, upstream issue
+	# emscripten-core/emscripten#16518
+	# Sed nonsense from https://stackoverflow.com/a/13383331
+	sed -i -n -e :a -e '1,6!{P;N;D;};N;ba' build/pyodide.asm.js
 	echo "globalThis._createPyodideModule = _createPyodideModule;" >> build/pyodide.asm.js
 	date +"[%F %T] done building pyodide.asm.js."
 
diff --git a/docs/project/changelog.md b/docs/project/changelog.md
index 03b7400c8..1acb5b8a0 100644
--- a/docs/project/changelog.md
+++ b/docs/project/changelog.md
@@ -71,6 +71,9 @@ substitutions:
   alias for `any`.
   {pr}`2277`
 
+- {{Fix}} Pyodide now loads correctly even if requirejs is included.
+  {pr}`2283`
+
 _February 19, 2022_
 
 ## Version 0.19.1