diff --git a/.gitignore b/.gitignore
index c15a4b125..5e949014c 100644
--- a/.gitignore
+++ b/.gitignore
@@ -17,6 +17,7 @@ __pycache__
 .pytest_cache/
 .vscode
 .venv*
+tsconfig.tsbuildinfo
 
 build
 ccache
diff --git a/Makefile b/Makefile
index b74180e33..398b05b61 100644
--- a/Makefile
+++ b/Makefile
@@ -133,7 +133,7 @@ node_modules/.installed : src/js/package.json src/js/package-lock.json
 	touch node_modules/.installed
 
 dist/pyodide.js src/js/generated/_pyodide.out.js: src/js/*.ts src/js/generated/pyproxy.ts node_modules/.installed
-	cd src/js && npm run tsc && node esbuild.config.mjs && cd -
+	cd src/js && npm run build && cd -
 
 src/core/stack_switching/stack_switching.out.js : src/core/stack_switching/*.mjs
 	node src/core/stack_switching/esbuild.config.mjs
diff --git a/docs/project/changelog.md b/docs/project/changelog.md
index 5cbc9e00d..45075057a 100644
--- a/docs/project/changelog.md
+++ b/docs/project/changelog.md
@@ -23,6 +23,9 @@ myst:
 - {{ Fix }} Fixed default indexURL calculation in Node.js environment.
   {pr}`4288`
 
+- {{ Fix }} Fixed a bug that webpack messes up dynamic import of `pyodide.asm.js`.
+  {pr}`4294`
+
 - {{ Enhancement }} Added experimental support for stack switching.
   {pr}`3957`, {pr}`3964`, {pr}`3987`, {pr}`3990`, {pr}`3210`
 
diff --git a/src/js/esbuild.config.mjs b/src/js/esbuild.config.mjs
index 6dee1350c..f47a55705 100644
--- a/src/js/esbuild.config.mjs
+++ b/src/js/esbuild.config.mjs
@@ -95,6 +95,9 @@ try {
       `try{Object.assign(exports,${name})}catch(_){}\nglobalThis.${name}=${name}.${name};\n//# sourceMappingURL`,
     );
 
+    // inject webpackIgnore comments
+    content = content.replaceAll("import(", "import(/* webpackIgnore */");
+
     writeFileSync(outfile, content);
   }
 } catch ({ message }) {
diff --git a/src/js/package.json b/src/js/package.json
index 6384bfff7..958451324 100644
--- a/src/js/package.json
+++ b/src/js/package.json
@@ -79,6 +79,7 @@
     "ws": false
   },
   "scripts": {
+    "build": "tsc --noEmit && node esbuild.config.mjs",
     "test": "npm-run-all test:*",
     "test:unit": "cross-env TEST_NODE=1 ts-mocha --node-option=experimental-loader=./test/loader.mjs --node-option=experimental-wasm-stack-switching -p tsconfig.test.json test/unit/**/*.test.*",
     "test:node": "cross-env TEST_NODE=1 mocha test/integration/**/*.test.js",
diff --git a/src/js/tsconfig.json b/src/js/tsconfig.json
index 78cb9b7e0..050827589 100644
--- a/src/js/tsconfig.json
+++ b/src/js/tsconfig.json
@@ -8,6 +8,7 @@
     "module": "ES2022",
     "moduleResolution": "node",
     "composite": true,
+    "tsBuildInfoFile": "tsconfig.tsbuildinfo",
     "strict": true,
     "noUnusedLocals": false,
     "types": ["node"],