diff --git a/packages/nlopt/test_nlopt.py b/packages/nlopt/test_nlopt.py
index 119f81bc9..b9bf24dc0 100644
--- a/packages/nlopt/test_nlopt.py
+++ b/packages/nlopt/test_nlopt.py
@@ -1,7 +1,12 @@
 from pyodide_build.testing import run_in_pyodide
 
 
-@run_in_pyodide(packages=["nlopt"])
+@run_in_pyodide(
+    packages=["nlopt"],
+    xfail_browsers={
+        "chrome": "nlopt set_min_objective triggers a fatal runtime error in chrome 89 see #1493",
+    },
+)
 def test_nlopt():
     import numpy as np
     import nlopt
diff --git a/packages/numcodecs/test_numcodecs.py b/packages/numcodecs/test_numcodecs.py
index 8d1dc1592..c234bdd3f 100644
--- a/packages/numcodecs/test_numcodecs.py
+++ b/packages/numcodecs/test_numcodecs.py
@@ -1,10 +1,15 @@
 from pyodide_build.testing import run_in_pyodide
 
 
-@run_in_pyodide(standalone=True, packages=["numcodecs", "numpy"])
+@run_in_pyodide(
+    standalone=True,
+    packages=["numcodecs", "numpy"],
+    xfail_browsers={
+        "chrome": "test_numcodecs triggers a recursion error in chrome",
+    },
+)
 def test_blosc():
     import numpy as np
-    from numcodecs import blosc
     from numcodecs.blosc import Blosc
     from numcodecs.zstd import Zstd
     from numcodecs.lz4 import LZ4
diff --git a/packages/pandas/test_pandas.py b/packages/pandas/test_pandas.py
index 064fc04f5..b14f445d8 100644
--- a/packages/pandas/test_pandas.py
+++ b/packages/pandas/test_pandas.py
@@ -51,6 +51,10 @@ def test_extra_import(selenium, request):
 @pytest.mark.skip_refcount_check
 def test_load_largish_file(selenium_standalone, request, httpserver):
     selenium = selenium_standalone
+    if selenium.browser == "chrome":
+        pytest.xfail(
+            "test_load_largish_file triggers a fatal runtime error in Chrome 89 see #1495"
+        )
 
     selenium.load_package("pandas")
     selenium.load_package("matplotlib")
diff --git a/pyodide_build/testing.py b/pyodide_build/testing.py
index 55d39e961..fa582bc1f 100644
--- a/pyodide_build/testing.py
+++ b/pyodide_build/testing.py
@@ -1,13 +1,27 @@
 import pytest
 import inspect
-from typing import Optional, List, Callable, Union
+from typing import Callable, Dict, List, Optional, Union
 import contextlib
 
 
+def _run_in_pyodide_get_source(f):
+    lines, start_line = inspect.getsourcelines(f)
+    num_decorator_lines = 0
+    for line in lines:
+        if line.startswith("def"):
+            break
+        num_decorator_lines += 1
+    start_line += num_decorator_lines - 1
+    # Remove first line, which is the decorator. Then pad with empty lines to fix line number.
+    lines = ["\n"] * start_line + lines[num_decorator_lines:]
+    return "".join(lines)
+
+
 def run_in_pyodide(
     _function: Optional[Callable] = None,
     standalone: bool = False,
     packages: List[str] = [],
+    xfail_browsers: Dict[str, str] = {},
     driver_timeout: Optional[Union[str, int]] = None,
 ) -> Callable:
     """
@@ -30,14 +44,12 @@ def run_in_pyodide(
 
     def decorator(f):
         def inner(selenium):
+            if selenium.browser in xfail_browsers:
+                xfail_message = xfail_browsers[selenium.browser]
+                pytest.xfail(xfail_message)
             with set_webdriver_script_timeout(selenium, driver_timeout):
                 if len(packages) > 0:
                     selenium.load_package(packages)
-                lines, start_line = inspect.getsourcelines(f)
-                # Remove first line, which is the decorator. Then pad with empty lines to fix line number.
-                lines = ["\n"] * start_line + lines[1:]
-                source = "".join(lines)
-
                 err = None
                 try:
                     # When writing the function, we set the filename to the file
@@ -51,7 +63,7 @@ def run_in_pyodide(
                                 true, // quiet_trailing_semicolon
                                 {!r} // filename
                             )""".format(
-                            source, inspect.getsourcefile(f)
+                            _run_in_pyodide_get_source(f), inspect.getsourcefile(f)
                         )
                     )
                     # When invoking the function, use the default filename <eval>
diff --git a/src/tests/test_testing.py b/src/tests/test_testing.py
index 36f7f5558..b311490d6 100644
--- a/src/tests/test_testing.py
+++ b/src/tests/test_testing.py
@@ -1,5 +1,6 @@
 import pathlib
-from pyodide_build.testing import run_in_pyodide
+from pyodide_build.testing import run_in_pyodide, _run_in_pyodide_get_source
+from textwrap import dedent
 
 
 def test_web_server_secondary(selenium, web_server_secondary):
@@ -13,6 +14,45 @@ def test_run_in_pyodide():
     pass
 
 
+def dummy_decorator(*args, **kwargs):
+    def func(f):
+        return f
+
+    return func
+
+
+@dummy_decorator(
+    packages=["nlopt"],
+    xfail_browsers={
+        "chrome": "nlopt set_min_objective triggers a fatal runtime error in chrome 89 see #1493",
+    },
+)
+def some_func():
+    import numpy as np
+    import nlopt
+
+    opt = nlopt.opt(nlopt.LD_SLSQP, 2)
+    opt.set_min_objective(f)
+    opt.set_lower_bounds(np.array([2.5, 7]))
+
+
+def test_run_in_pyodide_multiline_decorator():
+    assert (
+        _run_in_pyodide_get_source(some_func).strip()
+        == dedent(
+            """
+            def some_func():
+                import numpy as np
+                import nlopt
+
+                opt = nlopt.opt(nlopt.LD_SLSQP, 2)
+                opt.set_min_objective(f)
+                opt.set_lower_bounds(np.array([2.5, 7]))
+            """
+        ).strip()
+    )
+
+
 def test_assert(selenium):
     selenium.run_js(
         r"""