diff --git a/src/pyodide-py/pyodide/__init__.py b/src/pyodide-py/pyodide/__init__.py
index 141627da3..2e3fb6dcf 100644
--- a/src/pyodide-py/pyodide/__init__.py
+++ b/src/pyodide-py/pyodide/__init__.py
@@ -1,15 +1,15 @@
 from ._base import open_url, eval_code, eval_code_async, find_imports
 from ._core import JsException, create_once_callable, create_proxy  # type: ignore
-from ._importhooks import JsFinder
+from ._importhooks import jsfinder
 from .webloop import WebLoopPolicy
+from . import _state  # type: ignore # noqa
 import asyncio
 import sys
 import platform
 
-jsfinder = JsFinder()
+sys.meta_path.append(jsfinder)  # type: ignore
 register_js_module = jsfinder.register_js_module
 unregister_js_module = jsfinder.unregister_js_module
-sys.meta_path.append(jsfinder)  # type: ignore
 
 if platform.system() == "Emscripten":
     asyncio.set_event_loop_policy(WebLoopPolicy())
diff --git a/src/pyodide-py/pyodide/_importhooks.py b/src/pyodide-py/pyodide/_importhooks.py
index 1d5273d50..c30b09600 100644
--- a/src/pyodide-py/pyodide/_importhooks.py
+++ b/src/pyodide-py/pyodide/_importhooks.py
@@ -96,3 +96,6 @@ class JsLoader(Loader):
     # used by importlib.util.spec_from_loader
     def is_package(self, fullname):
         return True
+
+
+jsfinder = JsFinder()
diff --git a/src/pyodide-py/pyodide/_state.py b/src/pyodide-py/pyodide/_state.py
new file mode 100644
index 000000000..4e1acfbd2
--- /dev/null
+++ b/src/pyodide-py/pyodide/_state.py
@@ -0,0 +1,48 @@
+import __main__
+import sys
+import gc
+
+from ._core import JsProxy
+from ._importhooks import jsfinder
+
+
+def save_state() -> dict:
+    """Record the current global state.
+
+    This includes which Javascript packages are loaded and the global scope in
+    ``__main__.__dict__``. Many loaded modules might have global state, but
+    there is no general way to track it and we don't try to.
+    """
+    loaded_js_modules = {}
+    for [key, value] in sys.modules.items():
+        if isinstance(value, JsProxy):
+            loaded_js_modules[key] = value
+
+    return dict(
+        globals=dict(__main__.__dict__),
+        js_modules=dict(jsfinder.jsproxies),
+        loaded_js_modules=loaded_js_modules,
+    )
+
+
+def restore_state(state: dict):
+    """Restore the global state to a snapshot. The argument ``state`` should
+    come from ``save_state``"""
+    __main__.__dict__.clear()
+    __main__.__dict__.update(state["globals"])
+
+    jsfinder.jsproxies = state["js_modules"]
+    loaded_js_modules = state["loaded_js_modules"]
+    for [key, value] in list(sys.modules.items()):
+        if isinstance(value, JsProxy) and key not in loaded_js_modules:
+            del sys.modules[key]
+    sys.modules.update(loaded_js_modules)
+
+    sys.last_type = None
+    sys.last_value = None
+    sys.last_traceback = None
+
+    return gc.collect(2)
+
+
+__all__ = ["save_state", "restore_state"]
diff --git a/src/pyodide.js b/src/pyodide.js
index a4de0e73d..47b564a31 100644
--- a/src/pyodide.js
+++ b/src/pyodide.js
@@ -567,7 +567,6 @@ globalThis.languagePluginLoader = (async () => {
    * @param {string} name Name of js module to add
    * @param {object} module Javascript object backing the module
    */
-  // clang-format off
   Module.registerJsModule = function(name, module) { 
     Module.pyodide_py.register_js_module(name, module); 
   };
@@ -709,6 +708,11 @@ def temp(Module):
   Module.builtins = builtins.__dict__
   Module.pyodide_py = pyodide
 `);
+
+  Module.saveState = () => Module.pyodide_py._state.save_state();
+  Module.restoreState = (state) =>
+      Module.pyodide_py._state.restore_state(state);
+
   Module.init_dict.get("temp")(Module);
 
   // Wrap "globals" in a special Proxy that allows `pyodide.globals.x` access.
diff --git a/src/tests/test_pyodide.py b/src/tests/test_pyodide.py
index 1a49c7c44..8521fd1ec 100644
--- a/src/tests/test_pyodide.py
+++ b/src/tests/test_pyodide.py
@@ -339,3 +339,39 @@ def test_create_proxy(selenium):
         `);
         """
     )
+
+
+def test_restore_state(selenium):
+    selenium.run_js(
+        """
+        pyodide.registerJsModule("a", {somefield : 82});
+        pyodide.registerJsModule("b", { otherfield : 3 });
+        pyodide.runPython("x = 7; from a import somefield");
+        let state = pyodide._module.saveState();
+
+        pyodide.registerJsModule("c", { thirdfield : 9 });
+        pyodide.runPython("y = 77; from b import otherfield; import c;");
+        pyodide._module.restoreState(state);
+        state.destroy();
+        """
+    )
+
+    selenium.run(
+        """
+        from unittest import TestCase
+        raises = TestCase().assertRaises
+        import sys
+
+        assert x == 7
+        assert "a" in sys.modules
+        assert somefield == 82
+        with raises(NameError):
+            y
+        with raises(NameError):
+            otherfield
+        assert "b" not in sys.modules
+        import b
+        with raises(ModuleNotFoundError):
+            import c
+        """
+    )