diff --git a/docs/project/changelog.md b/docs/project/changelog.md
index dd051b53b..1f46e521e 100644
--- a/docs/project/changelog.md
+++ b/docs/project/changelog.md
@@ -55,6 +55,11 @@ substitutions:
   way.
   {pr}`2178`
 
+- {{Enhancement}} When Pyodide is loaded as an ES6 module, no global
+  `loadPyodide` variable is created (instead, it should be accessed as an
+  attribute on the module).
+  {pr}`2249`
+
 - {{Breaking}} Removed the `skip-host` key from the `meta.yaml` format. If
   needed, install a host copy of the package with pip instead. {pr}`2256`
 
diff --git a/src/core/error_handling.ts b/src/core/error_handling.ts
index 194ec6218..1d518b5e7 100644
--- a/src/core/error_handling.ts
+++ b/src/core/error_handling.ts
@@ -254,10 +254,6 @@ Module.handle_js_error = function (e: any) {
  *    easiest way is to only handle the exception in Python.
  */
 export class PythonError extends Error {
-  /**
-   * The Python traceback.
-   */
-  message: string;
   /**  The address of the error we are wrapping. We may later compare this
    * against sys.last_value.
    * WARNING: we don't own a reference to this pointer, dereferencing it
diff --git a/src/core/pyproxy.ts b/src/core/pyproxy.ts
index e01f7f6c2..e1bf3a275 100644
--- a/src/core/pyproxy.ts
+++ b/src/core/pyproxy.ts
@@ -52,18 +52,23 @@ export function isPyProxy(jsobj: any): jsobj is PyProxy {
 }
 API.isPyProxy = isPyProxy;
 
+declare var FinalizationRegistry: any;
+declare var globalThis: any;
+
 if (globalThis.FinalizationRegistry) {
-  Module.finalizationRegistry = new FinalizationRegistry(([ptr, cache]) => {
-    cache.leaked = true;
-    pyproxy_decref_cache(cache);
-    try {
-      Module._Py_DecRef(ptr);
-    } catch (e) {
-      // I'm not really sure what happens if an error occurs inside of a
-      // finalizer...
-      API.fatal_error(e);
+  Module.finalizationRegistry = new FinalizationRegistry(
+    ([ptr, cache]: [ptr: number, cache: PyProxyCache]) => {
+      cache.leaked = true;
+      pyproxy_decref_cache(cache);
+      try {
+        Module._Py_DecRef(ptr);
+      } catch (e) {
+        // I'm not really sure what happens if an error occurs inside of a
+        // finalizer...
+        API.fatal_error(e);
+      }
     }
-  });
+  );
   // For some unclear reason this code screws up selenium FirefoxDriver. Works
   // fine in chrome and when I test it in browser. It seems to be sensitive to
   // changes that don't make a difference to the semantics.
@@ -155,8 +160,8 @@ Module.pyproxy_new = function (ptrobj: number, cache?: PyProxyCache) {
 };
 
 function _getPtr(jsobj: any) {
-  let ptr = jsobj.$$.ptr;
-  if (ptr === null) {
+  let ptr: number = jsobj.$$.ptr;
+  if (ptr === 0) {
     throw new Error(jsobj.$$.destroyed_msg);
   }
   return ptr;
@@ -236,7 +241,7 @@ function pyproxy_decref_cache(cache: PyProxyCache) {
 }
 
 Module.pyproxy_destroy = function (proxy: PyProxy, destroyed_msg: string) {
-  if (proxy.$$.ptr === null) {
+  if (proxy.$$.ptr === 0) {
     return;
   }
   let ptrobj = _getPtr(proxy);
@@ -254,7 +259,7 @@ Module.pyproxy_destroy = function (proxy: PyProxy, destroyed_msg: string) {
   // Maybe the destructor will call JavaScript code that will somehow try
   // to use this proxy. Mark it deleted before decrementing reference count
   // just in case!
-  proxy.$$.ptr = null;
+  proxy.$$.ptr = 0;
   destroyed_msg += "\n" + `The object was of type "${proxy_type}" and `;
   if (proxy_repr) {
     destroyed_msg += `had repr "${proxy_repr}"`;
@@ -941,7 +946,7 @@ let PyProxyHandlers = {
     python_setattr(jsobj, jskey, jsval);
     return true;
   },
-  deleteProperty(jsobj: PyProxyClass, jskey: any) {
+  deleteProperty(jsobj: PyProxyClass, jskey: any): boolean {
     let descr = Object.getOwnPropertyDescriptor(jsobj, jskey);
     if (descr && !descr.writable) {
       throw new TypeError(`Cannot delete read only field '${jskey}'`);
@@ -955,7 +960,7 @@ let PyProxyHandlers = {
     python_delattr(jsobj, jskey);
     // Must return "false" if "jskey" is a nonconfigurable own property.
     // Otherwise JavaScript will throw a TypeError.
-    return !descr || descr.configurable;
+    return !descr || !!descr.configurable;
   },
   ownKeys(jsobj: PyProxyClass) {
     let ptrobj = _getPtr(jsobj);
@@ -1484,6 +1489,7 @@ export class PyBuffer {
       API.fatal_error(e);
     }
     this._released = true;
+    // @ts-ignore
     this.data = null;
   }
 }
diff --git a/src/js/index.test-d.ts b/src/js/index.test-d.ts
index b53bcf130..66e887a21 100644
--- a/src/js/index.test-d.ts
+++ b/src/js/index.test-d.ts
@@ -14,7 +14,7 @@ import {
   PyProxyCallable,
   PyBuffer,
   TypedArray,
-} from "../../build/pyodide";
+} from "./pyodide";
 
 async function main() {
   let pyodide = await loadPyodide({ indexURL: "blah" });
diff --git a/src/js/load-package.ts b/src/js/load-package.ts
index a25dcf6aa..d3f9f037a 100644
--- a/src/js/load-package.ts
+++ b/src/js/load-package.ts
@@ -46,7 +46,7 @@ const DEFAULT_CHANNEL = "default channel";
 // Regexp for validating package name and URI
 const package_uri_regexp = /^.*?([^\/]*)\.whl$/;
 
-function _uri_to_package_name(package_uri: string): string {
+function _uri_to_package_name(package_uri: string): string | undefined {
   let match = package_uri_regexp.exec(package_uri);
   if (match) {
     let wheel_name = match[1].toLowerCase();
@@ -202,6 +202,7 @@ function createLock() {
     let releaseLock: () => void;
     _lock = new Promise((resolve) => (releaseLock = resolve));
     await old_lock;
+    // @ts-ignore
     return releaseLock;
   }
   return acquireLock;
diff --git a/src/js/pyodide.ts b/src/js/pyodide.ts
index b803f10ff..0c9e4f2ba 100644
--- a/src/js/pyodide.ts
+++ b/src/js/pyodide.ts
@@ -233,7 +233,7 @@ export async function loadPyodide(config: {
   );
 
   setStandardStreams(config.stdin, config.stdout, config.stderr);
-  setHomeDirectory(config.homedir);
+  setHomeDirectory(config.homedir!);
 
   let moduleLoaded = new Promise((r) => (Module.postRun = r));
 
@@ -270,4 +270,3 @@ export async function loadPyodide(config: {
   pyodide.runPython("print('Python initialization complete')");
   return pyodide;
 }
-(globalThis as any).loadPyodide = loadPyodide;
diff --git a/src/js/pyodide.umd.ts b/src/js/pyodide.umd.ts
new file mode 100644
index 000000000..a7bfb8040
--- /dev/null
+++ b/src/js/pyodide.umd.ts
@@ -0,0 +1,3 @@
+import { loadPyodide } from "./pyodide";
+export { loadPyodide };
+(globalThis as any).loadPyodide = loadPyodide;
diff --git a/src/js/rollup.config.js b/src/js/rollup.config.js
index 36635721b..612f0629d 100644
--- a/src/js/rollup.config.js
+++ b/src/js/rollup.config.js
@@ -3,7 +3,7 @@ import { nodeResolve } from "@rollup/plugin-node-resolve";
 import { terser } from "rollup-plugin-terser";
 import ts from "rollup-plugin-ts";
 
-function config({ input, format, minify, ext = "js" }) {
+function config({ input, format, minify, ext }) {
   const dir = `build/`;
   // const minifierSuffix = minify ? ".min" : "";
   const minifierSuffix = "";
@@ -11,7 +11,7 @@ function config({ input, format, minify, ext = "js" }) {
     input: `./src/js/${input}.ts`,
     output: {
       name: "loadPyodide",
-      file: `${dir}/${input}${minifierSuffix}.${ext}`,
+      file: `${dir}/pyodide${minifierSuffix}.${ext}`,
       format,
       sourcemap: true,
     },
@@ -39,5 +39,5 @@ export default [
   // { input: "pyodide", format: "esm", minify: false, ext: "mjs" },
   { input: "pyodide", format: "esm", minify: true, ext: "mjs" },
   // { input: "pyodide", format: "umd", minify: false },
-  { input: "pyodide", format: "umd", minify: true },
+  { input: "pyodide.umd", format: "umd", minify: true, ext: "js" },
 ].map(config);
diff --git a/src/js/tsconfig.json b/src/js/tsconfig.json
index 16563b83b..47afc5a01 100644
--- a/src/js/tsconfig.json
+++ b/src/js/tsconfig.json
@@ -4,7 +4,6 @@
     "declaration": true,
     "lib": ["ES2021", "DOM"],
     "outDir": "../../build",
-    "rootDir": ".",
     "esModuleInterop": true,
     "target": "ES6",
     "module": "ES2020",
diff --git a/src/templates/module_test.html b/src/templates/module_test.html
index 3f145e5ce..6b4ad3dbb 100644
--- a/src/templates/module_test.html
+++ b/src/templates/module_test.html
@@ -19,7 +19,7 @@
     </script>
     <script type="module">
       import { loadPyodide } from "./pyodide.mjs";
-      window.loadPyodide = loadPyodidea;
+      window.loadPyodide = loadPyodide;
     </script>
   </head>
   <body></body>
diff --git a/src/tests/test_typeconversions.py b/src/tests/test_typeconversions.py
index b6d68e467..0811b5adb 100644
--- a/src/tests/test_typeconversions.py
+++ b/src/tests/test_typeconversions.py
@@ -322,7 +322,7 @@ def test_python2js_track_proxies(selenium):
         function check(l){
             for(let x of l){
                 if(pyodide.isPyProxy(x)){
-                    assert(() => x.$$.ptr === null);
+                    assert(() => x.$$.ptr === 0);
                 } else {
                     check(x);
                 }