diff --git a/projects/scipy/Dockerfile b/projects/scipy/Dockerfile
new file mode 100644
index 000000000..fd1047ebe
--- /dev/null
+++ b/projects/scipy/Dockerfile
@@ -0,0 +1,21 @@
+#!/usr/bin/python3
+# Copyright 2023 Google LLC
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#      http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+FROM gcr.io/oss-fuzz-base/base-builder-python
+RUN apt-get update && apt-get install -y \
+  gfortran libopenblas-dev liblapack-dev pkg-config
+RUN pip3 install --upgrade pip numpy
+RUN git clone https://github.com/scipy/scipy scipy
+COPY *.sh *py $SRC/
+WORKDIR $SRC/scipy
diff --git a/projects/scipy/build.sh b/projects/scipy/build.sh
new file mode 100644
index 000000000..780299da0
--- /dev/null
+++ b/projects/scipy/build.sh
@@ -0,0 +1,24 @@
+#!/bin/bash -eu
+# Copyright 2023 Google LLC
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#      http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+#
+###############################################################################
+
+git submodule update --init
+pip3 install .
+
+# Build fuzzers in $OUT.
+for fuzzer in $(find $SRC -name 'fuzz_*.py'); do
+  compile_python_fuzzer $fuzzer
+done
diff --git a/projects/scipy/fuzz_io_mio5.py b/projects/scipy/fuzz_io_mio5.py
new file mode 100644
index 000000000..cdafc86c9
--- /dev/null
+++ b/projects/scipy/fuzz_io_mio5.py
@@ -0,0 +1,41 @@
+#!/usr/bin/python3
+# Copyright 2023 Google LLC
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#      http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+import sys
+import atheris
+
+from io import BytesIO
+from scipy.io.matlab._mio5 import MatFile5Reader
+
+
+def TestOneInput(data):
+  if len(data) < 20:
+    return
+  try:
+    stream = io.BytesIO(data)
+    mat5_file_reader = MatFile5Reader(stream)
+    mat5_file_reader.get_variables()
+  except TypeError:
+    # Runs into this fast. Not interesting.
+    pass
+
+
+def main():
+  atheris.instrument_all()
+  atheris.Setup(sys.argv, TestOneInput)
+  atheris.Fuzz()
+
+
+if __name__ == "__main__":
+  main()
diff --git a/projects/scipy/fuzz_io_wavfile.py b/projects/scipy/fuzz_io_wavfile.py
new file mode 100644
index 000000000..7917b45dd
--- /dev/null
+++ b/projects/scipy/fuzz_io_wavfile.py
@@ -0,0 +1,42 @@
+#!/usr/bin/python3
+# Copyright 2023 Google LLC
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#      http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+import sys
+import atheris
+
+from scipy.io import wavfile
+
+
+def TestOneInput(data):
+  # Give enough bytes to pass initial checks
+  if len(data) < 20:
+    return
+  wav_filepath = "/tmp/temp.wav"
+  with open(wav_filepath, "wb") as f:
+    f.write(data)
+  try:
+    wavfile.read(wav_filepath)
+  except ValueError:
+    # Not interesting.
+    pass
+
+
+def main():
+  atheris.instrument_all()
+  atheris.Setup(sys.argv, TestOneInput)
+  atheris.Fuzz()
+
+
+if __name__ == "__main__":
+  main()
diff --git a/projects/scipy/project.yaml b/projects/scipy/project.yaml
new file mode 100644
index 000000000..6bd36e705
--- /dev/null
+++ b/projects/scipy/project.yaml
@@ -0,0 +1,10 @@
+fuzzing_engines:
+- libfuzzer
+homepage: https://github.com/scipy/scipy
+language: python
+main_repo: https://github.com/scipy/scipy
+sanitizers:
+- address
+- undefined
+vendor_ccs:
+- david@adalogics.com