diff --git a/projects/astc-encoder/astc_encode_decode_ise_fuzzer.cc b/projects/astc-encoder/astc_encode_decode_ise_fuzzer.cc
deleted file mode 100644
index 37deeb45a..000000000
--- a/projects/astc-encoder/astc_encode_decode_ise_fuzzer.cc
+++ /dev/null
@@ -1,35 +0,0 @@
-// Copyright 2020 Google Inc.
-//
-// Licensed under the Apache License, Version 2.0 (the "License");
-// you may not use this file except in compliance with the License.
-// You may obtain a copy of the License at
-//
-//     http://www.apache.org/licenses/LICENSE-2.0
-//
-// Unless required by applicable law or agreed to in writing, software
-// distributed under the License is distributed on an "AS IS" BASIS,
-// WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-// See the License for the specific language governing permissions and
-// limitations under the License.
-
-#include "astcenc_internal.h"
-
-#include <fuzzer/FuzzedDataProvider.h>
-#include <vector>
-
-static constexpr size_t kMaxOutBufSize = 64;
-
-extern "C" int LLVMFuzzerTestOneInput(const uint8_t *data, size_t size) {
-
-  FuzzedDataProvider stream(data, size);
-  int quantization_level = stream.ConsumeIntegral<int>();
-
-  // encode_ise and decode_ise will each write a max of 64 bytes to the buffer
-  std::vector<uint8_t> buffer = stream.ConsumeBytes<uint8_t>(kMaxOutBufSize);
-  uint8_t out[kMaxOutBufSize];
-
-  encode_ise(quantization_level, buffer.size(), buffer.data(), out, 0);
-  decode_ise(quantization_level, buffer.size(), buffer.data(), out, 0);
-
-  return 0;
-}
diff --git a/projects/astc-encoder/build.sh b/projects/astc-encoder/build.sh
index a38d60cdf..357812b46 100755
--- a/projects/astc-encoder/build.sh
+++ b/projects/astc-encoder/build.sh
@@ -27,7 +27,3 @@ for fuzzer in $SRC/*_fuzzer.cc; do
       -I. -std=c++14 $fuzzer $LIB_FUZZING_ENGINE $SRC/astc-encoder/Source/libastc.a \
       -o $OUT/$(basename -s .cc $fuzzer)
 done
-
-# Temporarily disable one fuzz target as requested in
-# https://github.com/google/oss-fuzz/issues/4481.
-rm $OUT/astc_encode_decode_ise_fuzzer