diff --git a/Misc/NEWS b/Misc/NEWS
index 0203e6cec40..e8ec6dc8e1e 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -115,6 +115,9 @@ Tests
 Build
 -----
 
+- Issue #15511: Drop explicit dependency on pythonxy.lib from _decimal
+  amd64 configuration.
+
 - Add missing PGI/PGO configurations for pywlauncher.
 
 - Issue #15645: Ensure 2to3 grammar pickles are properly installed.
diff --git a/PCbuild/_decimal.vcxproj b/PCbuild/_decimal.vcxproj
index 97b737aa970..98ba81db234 100644
--- a/PCbuild/_decimal.vcxproj
+++ b/PCbuild/_decimal.vcxproj
@@ -168,7 +168,6 @@
     </ClCompile>
     <Link>
       <BaseAddress>0x1D1A0000</BaseAddress>
-      <AdditionalDependencies>$(OutDir)python33_d.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">
@@ -192,7 +191,6 @@
     <Link>
       <SubSystem>NotSet</SubSystem>
       <BaseAddress>0x1D1A0000</BaseAddress>
-      <AdditionalDependencies>$(OutDir)python33.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'">
@@ -217,7 +215,6 @@
       <SubSystem>NotSet</SubSystem>
       <BaseAddress>0x1D1A0000</BaseAddress>
       <TargetMachine>MachineX64</TargetMachine>
-      <AdditionalDependencies>$(OutDir)python33.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
   </ItemDefinitionGroup>
   <ItemDefinitionGroup Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">
@@ -242,7 +239,6 @@
       <SubSystem>NotSet</SubSystem>
       <BaseAddress>0x1D1A0000</BaseAddress>
       <TargetMachine>MachineX64</TargetMachine>
-      <AdditionalDependencies>$(SolutionDir)\$(PlatformShortName)\python33.lib;%(AdditionalDependencies)</AdditionalDependencies>
     </Link>
   </ItemDefinitionGroup>
   <ItemGroup>