diff --git a/Misc/NEWS.d/next/Windows/2021-11-26-18-17-41.bpo-45901.c5IBqM.rst b/Misc/NEWS.d/next/Windows/2021-11-26-18-17-41.bpo-45901.c5IBqM.rst
new file mode 100644
index 00000000000..2cb872bffe0
--- /dev/null
+++ b/Misc/NEWS.d/next/Windows/2021-11-26-18-17-41.bpo-45901.c5IBqM.rst
@@ -0,0 +1,4 @@
+When installed through the Microsoft Store and set as the default app for
+:file:`*.py` files, command line arguments will now be passed to Python when
+invoking a script without explicitly launching Python (that is, ``script.py
+args`` rather than ``python script.py args``).
diff --git a/PC/layout/support/appxmanifest.py b/PC/layout/support/appxmanifest.py
index 747c97a0069..15119b02a80 100644
--- a/PC/layout/support/appxmanifest.py
+++ b/PC/layout/support/appxmanifest.py
@@ -430,7 +430,7 @@ def get_appxmanifest(ns):
         ["python", "python{}".format(VER_MAJOR), "python{}".format(VER_DOT)],
         PYTHON_VE_DATA,
         "console",
-        ("python.file", [".py"], '"%1"', "Python File", PY_PNG),
+        ("python.file", [".py"], '"%1" %*', "Python File", PY_PNG),
     )
 
     add_application(
@@ -441,7 +441,7 @@ def get_appxmanifest(ns):
         ["pythonw", "pythonw{}".format(VER_MAJOR), "pythonw{}".format(VER_DOT)],
         PYTHONW_VE_DATA,
         "windows",
-        ("python.windowedfile", [".pyw"], '"%1"', "Python File (no console)", PY_PNG),
+        ("python.windowedfile", [".pyw"], '"%1" %*', "Python File (no console)", PY_PNG),
     )
 
     if ns.include_pip and ns.include_launchers: